Sage is used for cleansing and purifying the energies within a space. Once the space has been cleansed you would follow up with burning Palo Santo to balance the space and welcome in calm, positive, and healing energies.
Sometimes you may not want to do a deep sage cleanse but rather just calm your vibes and soothe your soul. For this just burn Palo Santo on its own it's a powerful energy shifting smudging tool. I love burning Palo in the mornings before I begin my yoga routine and in the evenings as I sip my wine and journal my thoughts.